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半滑舌鳎日粮中补充胆汁酸是一种改善肝脏健康状况的有效策略

Dietary supplementation of bile acids in tongue sole (Cynoglossus semilaevis) a promising strategy to improve hepatic health status

作者：Li, Yangzhen, Shengpeng Wang, Yuanri Hu, Jiayu Cheng, Xiangming Cheng, Peng Cheng and Zhong-kai Cui.

发布期刊：Fish & shellfish immunology (2021): n. pag.

为研究胆汁酸对半滑舌鳎肝脏健康状况的有益影响，开展了一项为期10周的试验。在商品基础日粮中添加不同水平的胆汁酸配制成3种试验日粮：对照组（基础日粮）、低水平组（胆汁酸300 mg/kg+基础日粮）和高水平组（胆汁酸900 mg/kg+基础日粮）。试验结束后，测定了半滑舌鳎的生长性能和存活率，以及肝脏的理化指标，包括肝功四项、抗氧化五项、脂质代谢五项和3种消化酶活性。此外，还检测了肝脏中3个生长相关基因和3个免疫相关基因的mRNA转录水平。结果表明，低水平和高水平胆汁酸添加组，半滑舌鳎的生长性能和存活率都有显著提高。此外，检测的肝脏理化指标和实时荧光定量PCR 结果表明，半滑舌鳎肝脏的抗氧化能力、能量代谢、消化能力和免疫反应均有所提高。最后，这些发现为日粮中添加胆汁酸对半滑舌鳎肝脏健康的有益影响提供了更广阔的视野。

A 10-week feeding trial was conducted to investigate the beneficial effects of bile acids (BAs) on hepatic health status in tongue sole (Cynoglossus semilaevis). Three experimental diets were prepared with different levels of BA inclusion in the commercial basal diet: control group (CT: 0 mg/kg basal diet), low-level group (BA1: 300 mg/kg basal diet), and high-level group (900 mg/kg basal diet). At the end of the feeding trial, growth performance and survival rate were measured, as well as numerous physiological and biochemical parameters of the liver, including four hepatic function indices, five antioxidant indices, five lipid metabolism parameters, and three digestive enzyme activities. Moreover, the mRNA expression levels of three growth-related genes and three immune-related genes in the liver were assayed. Results showed that growth performance and survival were substantially improved in both low- and high-level BA inclusive groups. Further, the tested liver physiological and biochemical parameters combined with the quantitative real-time PCR results revealed enhanced antioxidant capacity, energy metabolism, digestive ability, and immune response. Finally, these findings provide a wider spectrum of the beneficial effects of dietary BAs on liver health in tongue sole.

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