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在肉鸡日粮中添加高剂量胆汁酸补充对生长性能、血液代谢物和器官发育的影响

Effect of high dose of bile acids supplementation in broiler feed on growth performance, clinical blood metabolites, and organ development

作者：Wenqing Lai, Aizhi Cao, Juntao Li, Wenjuan Zhang, Liying Zhang.

发布期刊：Journal of Applied Poultry Research.. 2018 Dec;27(4):532-539.

胆汁酸作为一种新型添加剂，常应用于动物日粮中以增强脂肪吸收。目前，胆汁酸在禽类养殖的应用中鲜有研究，其安全性研究也未曾报道。因此，本研究进行了亚慢性肉鸡安全性研究，以评估高剂量胆汁酸是否会影响肉鸡的健康。选取1日龄AA肉仔鸡324羽，随机分为3个处理，每个处理6个重复，每个重复18羽。分别饲喂添加0、80（推荐的有效剂量）和400 mg/kg（推荐的有效剂量的5倍）胆汁酸的玉米-豆粕型日粮，连续饲喂42天。在整个试验过程中，进行了临床观察和生长性能测定。试验结束后，对肉鸡进行全面的宰后检查：采集血液样本进行临床病理学检测，对相关的器官进行称重，并取对相关组织进行组织病理学检查。相关结果显示，高剂量胆汁酸饲喂的肉鸡，未观察到毒理学意义上的变化。因此，400 mg/kg的高胆汁酸添加剂量，对肉鸡未观察到不良影响。

Bile acids are intended for use in animal feed as a novel feed additive to enhance fat absorption. As far as we know, few studies in avian species have been reported, and a safety study of bile acids has not been done. Therefore, a subchronic broiler chicken safety study was conducted to evaluate whether or not high-dose bile acids could affect the health of broiler chickens. A total of 324 1-day-old Arbor Acres broiler chickens were randomly assigned to 3 treatments with 6 replicates of 18 broiler chickens each. Broiler chickens were fed a corn-soybean meal diet supplemented with 0, 80 (the recommended available dose, RAD), and 400 mg/kg (5-fold of RAD) of bile acids for 42 d, respectively. Throughout the study, clinical observation and growth performance were measured. At the end of the study, broiler chickens were subjected to a full postmortem examination: blood samples were collected for clinical pathology, selected organs were weighed, and specified tissues were taken for subsequent histopathological examination. No treatment-related changes considered to be of toxicological significance were observed. Therefore, a nominal bile acids inclusion of 400 mg/kg was considered to be the no-observed adverse-effect level.

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