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猪源胆汁酸对断奶仔猪的生长性能、抗氧化能力、血液代谢物和营养物消化率的影响

Effects of porcine bile acids on growth performance, antioxidant capacity, blood metabolites and nutrient digestibility of weaned pigs

作者：Cao, A., Lai, W., Zhang, W.W., Dong, B., Lou, Q.Q., Han, M.M., He, D., Gai, X., Sun, Y.B., & Zhang, L.Y.

发布期刊：Animal Feed Science and Technology, 2021:114931.

本试验旨在研究猪源胆汁酸对断奶仔猪的生长性能、抗氧化能力、血液代谢物和营养物消化率的影响。180头断奶仔猪随机分为5组，进行为期42天的喂养试验。对照组饲喂玉米-豆粕基础日粮，实验组添加60、80、100、120 mg/kg 胆汁酸的基础日粮。每个处理组选取6头断奶仔猪，于第28天和第42天进行采血。从第39天到第42天，采集每个栏的新鲜粪便样品。实验结果表明，添加胆汁酸显著改善了断奶仔猪在第29-42天和第1-42天的日均增重（线性，P < 0.05；二次方，P < 0.05）。从第1天到第28天，与对照组相比，血清超氧化物歧化酶和谷胱甘肽过氧化物酶的活性显著增加（P < 0.01）。血清谷胱甘肽含量呈线性和二次曲线增加（P < 0.05和P < 0.01），与胆汁酸的添加量呈正相关。在第29-42天，血清超氧化物歧化酶（线性，P < 0.05；二次方，P < 0.01）和谷胱甘肽过氧化物酶（P < 0.01）的活性，以及谷胱甘肽（线性，P < 0.01；二次方，P < 0.01）和总抗氧化能力（P < 0.05）的水平随着胆汁酸添加量的增加而增加。此外，与对照组相比，饲喂80和100 mg/kg 胆汁酸的断奶仔猪干物质，粗脂肪消化率和总能显著提高（P < 0.01）。这些结果表明，日粮中添加猪源胆汁酸，可提高断奶仔猪的营养物质消化率、提高抗氧化能力，改善生长性能。

This experiment was conducted to investigate the effects of porcine bile acids (BA) on growth performance, antioxidant capacity, blood metabolites and nutrient digestibility of weaned pigs. One hundred and eighty pigs were assigned into five groups for 42 days. Pigs were fed a corn-soybean meal basal diet or a basal diet supplemented with 60, 80, 100 or 120 mg/kg BA. Six pigs per treatment were selected for blood sampling at days 28 and 42. Fresh fecal samples were collected from each pen from day 39 to 42. Supplementation with BA improved average daily gain (linear, P < 0.05; quadratic, P < 0.05) of pigs during days 29-42 and 1-42. From day 1 to 28, activities of serum superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were increased (P < 0.01) compared with the control treatment. Serum glutathione (GSH) content was elevated linearly and quadratically (P < 0.05 and P < 0.01) in response to BA supplementation. During day 29 to 42, activities of SOD (linear, P < 0.05; quadratic, P < 0.01) and GSH-Px (P < 0.01), and the levels of GSH (linear, P < 0.01; quadratic, P < 0.01) and total antioxidant capacity (TAOC) (P < 0.05) increased with increasing levels of BA supplementation. Moreover, pigs fed 80 and 100 mg/kg porcine BA had greater (P < 0.01) dry matter (DM), ether extract (EE) and gross energy (GE) digestibility compared to control-fed pigs. These results suggested that dietary supplementation with porcine BA can improve growth performance, antioxidant capacity and nutrient digestibility of weaned pigs.

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